Worst Case and MAC calculation - Multi Active

[Jay Naidoo]

Hi

Can some explain how to calculate MAC for multiple active products eg. Paracetamol (400 mg), Codeine Phosphate (8 mg) and Caffiene(30 mg).
What do are use as the target compound? Paracetamol is the least soluble and Codeine is the most soluble.
Do I include the most potent component (codeine) in the MAC calculation?

Paracetamol - least soluble, highest dose, most potentially contaminating.
Codeine - Most potent, least contaminating.

Water is use to wash.

Jay